Get this from a library prostatic obstruction pathogenesis and treatment christopher r chapple the book critically and concisely reviews current basic science data on the bladder and prostate as well as the way in which the function of both is altered in benign prostatic hyperplasia to cause . Overview benign prostatic hyperplasia bph also called prostate gland enlargement is a common condition as men get older an enlarged prostate gland can cause uncomfortable urinary symptoms such as blocking the flow of urine out of the bladder. Benign prostatic hyperplasia bph also known as benign prostatic hypertrophy is a histologic diagnosis characterized by proliferation of the cellular elements of the prostate cellular accumulation and gland enlargement may result from epithelial and stromal proliferation impaired preprogrammed cell death apoptosis or both. Pathophysiology of bph historical perspective the pathophysiology of bladder outlet obstruction in men with bph has been attributed to both static and dynamic factors 7 the static obstruction is due to the bulk enlargement of the prostate encroaching upon the prostatic urethra and bladder outlet whereas the dynamic obstruction is related to the tension of prostate smooth muscle
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